Sentence examples for is highly refractory from inspiring English sources

Dr. Robert J. Motzer of Memorial Sloan-Kettering Cancer Center in New York, who was not involved in the study, said: "This is a novel treatment strategy that has produced encouraging results, in a cancer that is highly refractory to conventional therapy.

Pancreatic ductal adenocarcinoma (PDA) is a stroma-rich tumour that is highly refractory to systemic therapies.

These observations demonstrate that PCH in somatic cells is highly refractory to PRC2 activity.

The results remain poor because mRCC is highly refractory to therapy, including radiation, hormones and chemotherapy (Motzer and Russo, 2000).

As malignant melanoma is highly refractory to conventional chemotherapeutic strategies, we aimed to examine the potential enhancement of tumor cell response rates by collateral inhibition of the anti-apoptotic BCL-2 family members with ABT-737.

Surgical resection remains the mainstay of therapy for localised RCC, and metastatic RCC is highly refractory to conventional radiation therapy and chemotherapy (Bilim et al, 2009; Thompson Coon et al, 2009).

Certain minerals that are highly refractory both in nature and in the laboratory (e.g., zircon) may require five days or more at temperatures near 220 °C (428 °F).

Because they are highly refractory, these compounds have been much investigated for use as fuels for nuclear reactors.

Also, HT-29 colorectal tumor xenografts, which are highly refractory to paclitaxel, showed complete regression after AZ10992 administered at 30 mg/kg/day (seven injections for 4-days).

Hepatocellular carcinoma (HCC) represents one of the leading causes of cancer death and has proved to be highly refractory to treatment.

Both diabetes mellitus and BD are highly refractory: less than half of the participants in the National Health and Nutrition Examination Survey (NHANES) met glycemic control goals (Koro et al. 2004).