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The intravenous pathogenicity index of GD01/2014 was 3.0, which indicates that the isolate is highly pathogenic for chickens.
However, it is highly pathogenic for domestic poultry, causing significant mortality in chickens and turkeys.
Taken together, these data suggest that this virus is highly pathogenic for domestic rabbits and belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Simplexvirus.
Previous studies demonstrate that VN/04 H5N1 virus is highly pathogenic for mice as a result of its rapid systemic spread [34], [35].
Finally, the number of basic amino acids (lysine or arginine) in the cleavage site between HA1 and HA2 determines whether the virus is highly pathogenic for birds [22], [23].
Strain ML64 is highly pathogenic for chicken and turkey embryos and can be transmitted by air (6, 9 ).
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Both viruses were shown to be highly pathogenic for chickens (intravenous pathogenicity index 3).
Gochang1 virus has been shown to be highly pathogenic for chickens (intravenous pathogenicity index 3.0) (6 ).
Both H5N8 subtype isolates were highly pathogenic for chickens and showed moderate pathogenicity for mice.
The corresponding isolate, A/Turkey/Suzdalka/Nov-1/05, from turkey spleen was highly pathogenic for chickens in the laboratory intravenous pathogenicity index test.
(iii) Would such a virus be highly pathogenic for humans?
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