Similarly, sometimes, a species is highly phylogenetically distant from the seed organism, making it the case that utilization of profile hidden Markov models from other phyla is more suitable than own phyla's profile.
For the mutant V240C we obtained a high coupling efficiency to the DNA, possibly because this attachment site is highly exposed and distant from lipid/detergent bound regions (Fig. 1 A).
This 60 aa domain is highly conserved across distant species from insects to mammals [ 20].
Furthermore, EpCAM is highly expressed on distant metastasis (Litvinov et al, 1994).
Osteosarcoma is highly aggressive with distant metastasis, and approximately 20% of patients have metastases in lung or bone at diagnosis.
(1) This disease is highly aggressive, and distant metastasis develop in approximately 45% of patients despite treatment with a potent neoadjuvant, which consists of high doses of multiple chemotherapeutic agents.
WB-MRI is highly sensitive in detecting distant metastases, PET/CT is superior in lymph node staging.
Nothing is known about the function of KAP-2 protein, but it probably possesses important housekeeping functions as it is highly conserved among phylogenetically distant organisms.
Our data revealed that already small tumors display the metastatic signature, and recent results show that the molecular program established in a primary breast carcinoma is highly preserved in its distant metastasis.
When morphological imaging fails to find distant metastasis and distant metastasis is highly suspected, a positron-emission tomography-CT (PET-CT) examination should be done to acquire accurate clinical staging.
