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Although it remains unknown whether disease-mutations in RPGR or RPGRIP1 promote deposits of RPGRIP1 in photoreceptor neurons, the propensity for formation of intracellular deposits by RPGRIP1α1 in the absence of RPGR expression across all cells examined in culture is a pathological feature, which is hallmark to many neurodegenerative diseases (Douglas and Dillin, 2010).
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There are hallmarks to the practice of GHD that are worth noting.
Genetic alterations, response to growth and inhibitory signals, resistance to apoptosis, altered cellular communications and intracellular signalling pathways are hallmarks common to IPF and cancer [18].
Clearly, sustained proliferative signaling, evasion of growth-suppressing signals and replicative immortality are hallmarks leading to sustained proliferation.
Or are Hallmark and its hard-to-find spot on the dial the problem?
Moross says he wants to be "Hallmark 2.0".
Substrate and catalytic promiscuities are believed to be hallmark characteristics of primitive enzymes, serving as evolutionary starting points from which greater specificity is acquired following application of selective pressures (Khersonsky et al. 2006).
The genes Foxp3, Nrp1, Clta4, Tnfrsf18 / Gitr, Il2ra / Cd25, Itgae / CD103, Ikzf4 / Eos, Gpr83 have been reported to be hallmark genes for Treg cells [ 31, 32].
If there was a hallmark to Meyer's coaching style, both on and off the field, it was his relentlessness.
The binding of TFs and cofactors to promoters are hallmarks of expression, by signalling to the Pol II machinery the appropriate positional coordinates.
In poorer and blacker neighborhoods, street gangs have been a hallmark to the extent that the middle class has hardly paid attention.
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CEO of Professional Science Editing for Scientists @ prosciediting.com