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the core is further substituted by one additional sugar attached to position 6 of ring II.
In 4,5- aminoglycosides, the core is further substituted by one (ribostamycin), two (neomycin, paromomycin) or three (lividomycin) additional sugars attached to position 5 of ring II, whereas in 4,6- aminoglycosides (gentamicin, tobramycin, kanamycin, etc).
In blood groups A and B, the H-antigen is further substituted by an α-galactosamine or galactose residue, respectively (e.g., 3 a and 4).
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These compounds were further substituted with different primary and secondary amines.
In the second analog, AT2S, Trp8 was further substituted by DTrp8 in our AT1S motif to convey additional metabolic stability.
A fourth anchor bearing a 3,4-dibromomaleimide ring (DOG-DBM) was also unprecedentedly synthesized, to be further substituted by two thiols.
The chloride atoms on the triziane rings were further substituted by either electron donating amines, or an electron withdrawing thiomethyl moiety.
Most of the surface water will be partly replaced by the ethanol during ethanol washing, while the rest hydrogel-captured water can be further substituted by the ethanol during the SCD treatment.
In the first series, the relative proportion of a biphenyl and a phenyl unit was varied through copolymerisation; in the second, the phenyl ring system was further substituted with an aliphatic side-chain, in order to promote additional disruption to any solid-state ordering.
The latter can be further substituted by α-1,2-linked fucosyl residues [ 112].
To address the functional role of this motif in PepTSt, Glu22, Glu25, Arg26, Tyr29 and Ty30 were mutated sequentially to alanine (Supplementary Table 1); however, as the Arg26Ala mutant did not express this was further substituted for lysine.
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CEO of Professional Science Editing for Scientists @ prosciediting.com