Based on these complete in vitro biology and physicochemical data, some of the chemical families were further progressed by the tuberculosis group at GSK.
However, compounds with artificial activity readouts are often not recognized and are further progressed, which presents a substantial problem for drug discovery.
For example, open chain exercises (e.g., straight leg raises) are progressed to closed chain exercises (e.g., mini-wall squats) that are further progressed to activities such as mini-squats.
It could be that the boys with unrecognized CD were further progressed in their disease at baseline because they were not as likely as the girls to have been found in clinical practice.
It has been suggested in this study that patients should continue their functional strengthening exercise programme for at least one year and that this programme should be further progressed as their function improved.
Adding to the previous report on Hg2+-induced echinocytic changes in human erythrocytes (Suwalsky et al. 2000), we found that echinocytes can be further progressed into spherocytes by prolonged exposure to Hg2+.
These criteria yielded 777 compounds that were further progressed to MIC determination against H37Rv under standard 7H9 medium growth conditions, resulting in 177 positives showing an MIC against H37Rv of <10 μ m and a therapeutic index of (HepG2 IC50/MIC)>50.
Osborne said of the latest reduction in the stake: "This is further progress in returning Lloyds Banking Group to private ownership, reducing our national debt and getting taxpayers' money back.
That doesn't mean there can't be further progress".
