Sentence examples for is functionally constrained from inspiring English sources

For example, several invertebrate genomes contain operons (e.g. nematodes [3] and ascidians [4]), where gene order is functionally constrained by the necessity to generate a poly-cistronic messenger RNA.

We estimate that 15% of genomic sequence is functionally constrained between G. magnirostris and zebra finch.

In this method, the rationale for homology assessment is accounting for the fact that secondary structure is functionally constrained in ribosomal RNA.

The frequency of deletion polymorphisms monotonically decreases as the distance to TSS decreases, while no significant variation in nucleotide polymorphism frequency was observed along the promoter region, suggesting that the distance between TFBSs and the TSS is functionally constrained.

None of the 24 amino acids putatively under positive selection in Brassicaceae are located in predicted transmembrane domains [ 53], indicating that in Brassicaceae evolution of predicted channel-forming residues is functionally constrained.

Since HM00022 codes for a protein that serves a known important function (Enoyl-CoA Hydratase), it may have experienced greater selective pressure to be functionally constrained compared to other genes discussed here [ 29].

This is partially explained by numerous gene-poor regions that display a remarkable degree of noncoding conservation with non-mammalian vertebrates, suggesting that they are functionally constrained.

Just as shrew teeth cannot grow too large or sprout needle-sharp peaks, points and their modular components cannot grow too large or small, cannot sprout multiple points on their edges or faces, cannot grow too thick or thin, and otherwise are functionally constrained (e.g., Hughes 1997; Wilhelmsen 2001).

The three central nucleotides, GAA or TTC, are highly conserved in D. melanogaster [10], implying they are functionally constrained.

The level of sequence divergence amongst orthologous CPRs, for example, is often low outside of the conserved chitin-binding domain despite a high level of divergence among paralogues, indicating that these regions are functionally constrained.

The predicted first NBD of ABCB5 shows comparable levels of purifying selection to the NBDs of the other ABCB genes, revealing that it has been functionally constrained throughout mammalian evolution, and confirming that ABCB5 has evolved as a full transporter.