Sentence examples for is functionally compromised from inspiring English sources

In contrast to these latter variants, our data suggest that the G787R variant is functionally compromised and may be a rare cause of hereditary colorectal cancer.

Moreover, there are pathological conditions, such as Dent's Disease and Lowe Syndrome, in which megalin expression is functionally compromised [14], [63], [64].

As other studies of the CtBP-dependent suppression of chemosensitivity have focused on cells in which the p53 response is functionally compromised, a role of this p53 response in modifying CtBP-dependent chemosensitivity has not yet been established.

In [ PSI + ] strains, Sup35 is functionally compromised, leading to stop-codon read-through and the formation of white or pink colonies on rich medium, but in [ psi−] strains, termination is faithful at the PTC, leading to the formation of red colonies on rich medium (Chernoff et al., 1995).

CD8low cells are characterized by an activated phenotype, are functionally compromised in vitro, and are slated for deletion in vivo.

Indeed, despite the robust functionality exhibited by stem cells in artificially created bone defects in animal models, predictable tissue regeneration is not achieved when they are applied to treat periodontitis-caused tissue loss, at least in part because these cells may be functionally compromised in an inflammatory environment6.

However, in some other conditions, TIDCs are functionally compromised.

Although eNOS is an important player in regulating vascular function with anti-atherogenic properties [47, 48], reports on its role in hypercholesterolemia are mixed: Hypercholesterolemia was reported to upregulate eNOS expression in the rabbit aorta [49], while it may be functionally compromised and contribute to endothelial dysfunction in CAD patients [50].

In vivo, pathogen-infected APCs may be functionally compromised and DCs may not be directly infected.

Those cells seem to be functionally compromised with inactivated Na+ channels, although blocking Na+ channels alone could not reproduce desynchronized action potentials within a field of view of microscope.

If the cells are functionally compromised, their reabsorption rate will decline.