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We employed a non-immortalized, non-transformed primary fibroblast cell line that is fully competent for IRF3 signaling and is susceptible and permissive to infection by HSV-1.
Whereas the topoisomerase monomer is fully competent for strand cleavage, the Cre monomer likely requires allosteric activation by a neighboring monomer to become cleavage proficient [3], [6].
However, the ppr1Δ-null allele is fully competent for URA2 transcription.
These findings support the hypothesis that the chaperone-mediated rescued Parkin(C289G) is fully competent for enhancing mitophagy of damaged mitochondria.
It is also remarkable that we detect no OM biogenesis defect in strains carrying waaL15, demonstrating that the Lpt system is fully competent for the transport and assembly of LPS* despite the addition of both unnatural sugars and peptide stems.
Inversion reactions were performed in the presence and absence of Fis for 0, 1, 2, and 5 min. Hin-R48A/K51A exhibits 10-fold slower kinetics than Hin-wt under Fis-activating conditions, but is fully competent for Fis-independent inversion when coupled to the hyperactivating mutation Hin-H107Y.
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She was fully competent for the job, [even] having never done it before.
In contrast to Notch1 receptors, S1-resistant Notch2 receptors are fully competent for cell surface delivery and for activation by ligands.
These results imply that mutations at positions 313 and 314 that do not inhibit formation of stable channels are fully competent for protein translocation.
Thus, we believe that patients with the ATG16L1*300A allele are likely to be fully competent for the homeostatic functions of autophagy, yet may exhibit altered responses to bacterial components and infection in the gut milieu, where antigen burden is high.
However, Notch1 and Notch2 receptors engineered to resist S1 cleavage exhibit unexpected differences in surface delivery and signaling competence: S1-resistant Notch1 receptors exhibit decreased, but detectable, surface expression and ligand-mediated receptor activation, whereas S1-resistant Notch2 receptors are fully competent for cell surface delivery and for activation by ligands.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com