Our analyses show that in β-cells Insm1 is frequently bound to chromatin together with Neurod1 and Foxa2, two well characterized transcription factors that control mature β-cell function (Naya et al, 1997; Lantz et al, 2004; Gao et al, 2007, 2010; Gu et al, 2010; Mastracci et al, 2013).
Carlevaro-Fita, J., Rahim, A., Guigo, R., Vardy, L. A. & Johnson, R. Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells.
Lineage-specific dynamic alterations in DNA methylation and H3K4me1 are evident at putative distal regulatory elements that are frequently bound by pluripotency factors in the undifferentiated hESCs.
Transcriptional enhancers are frequently bound by a set of transcription factors that collaborate to activate lineage-specific gene expression.
TAL1 is also frequently bound to introns as shown for the Cdk6 regulator of T-cell differentiation (Grossel and Hinds, 2006), whose expression is upregulated by TAL1 in T-ALL cells.
Thus, we conclude that the group of TSS-proximal predicted sites displayed higher protein occupancy at predicted sites when compared to the randomly selected binding sites, but that it was not the overall promoter region that was more frequently bound by the protein.
They stated that genes positively regulated by HSF1 were more likely bound at the promoter, whereas negatively regulated were more frequently bound in distal regions.
Performance and resilience are frequently tightly bound in a network design.
For example, consensus binding motifs are highly enriched in genomic binding sites for the transcriptional repressor REST [7], whereas other factors, including the neuronal activity-regulated transcription factor CREB, are frequently found bound to regions that lack a consensus binding sequence [8].
Small molecules that can intercalate into nucleic acids have been approved for cancer therapy in the past and can be frequently found bound to their targets in the PDB.
However, there was a large, significant difference involving binding by RBPs: RBP-encoding mRNAs are more frequently bound by RBPs than TF mRNAs and mRNAs in general.
