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And it is often in school that problematic behaviour is first noticed in children who are not coping.
The disease frequently is first noticed following an infection and is chronic, with periods of intestinal upset, diarrhea, and failure to grow and gain weight, interspersed with periods of apparent normality.
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The issue was first noticed at 7.43am.
The race was first noticed by Buzzfeed's Matt Bellassai.
It was soon afterwards that the bag was first noticed.
"It was our bad luck that it was first noticed here," Schmallenberg's mayor has said.
A crack in the massive PIG ice sheet was first noticed by NASA scientists in October 2011.
The problem was first noticed by investors in the middle of the last decade.
The search still has the same results, at least two days after it was first noticed.
The issue was first noticed about four years ago by Cardiff landlord John Winter.
(It was first noticed when the sea temperature off Peru rose by several degrees overnight).
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