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Ubiquitination proceeds along an enzymatic cascade, in which ubiquitin is first activated by the ubiquitin-activating enzyme E1, conjugated by an E2 ubiquitin-conjugating enzyme, and finally covalently linked to the substrate by a specific E3 ubiquitin ligase [11],[11].
Mature SUMO is first activated by a heterodimeric activator protein via the formation of a thioester linkage.
Our study revealed that, in normal SH-SY5Y cells, the activity of caspase-8, which is first activated by Fas, was increased at 6 h after reperfusion and maintained over the first 24 h.
Autophagy is activated before apoptosis, suggesting that autophagy is first activated as a protective mechanism followed by apoptosis activation at longer time when the stress is not relieved.
The embryo (germ) is first activated by uptake of water, which enables it to produce gibberellin.
The epoxy ring is first activated by the –OH group via a hydrogen bond interaction and the quaternary ammonium cations via electronic interaction (a).
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To determine whether E6 inhibits activity, p53 was first activated by 5 nM OA, a protein phosphatase 2A (PP2A) inhibitor.
Briefly, Sn IV) Ce6 dye (MW 850.21) (Frontier Scientific, Logan, UT, USA) was first activated by EDC, and then fVII protein was added to the activated dye for conjugation.
Interestingly, DN1 T cells were first activated in the lung draining lymph node and seemed to have faster activation and proliferation kinetics compared to Ag85B-specific CD4+ T cells.
It was announced in October 2014, and was first activated for the having been activated for the earthquake in Nepal in April 2015.
It needs to be first activated by KatG.
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CEO of Professional Science Editing for Scientists @ prosciediting.com