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Because elevated blood pressure is a systemic phenomenon, an emergent property that is far downstream from the function of individual genes, researchers are beginning to investigate the association of candidate genes with endophenotypes, or precursors to hypertension to increase the power of finding an association.
This latter STAT upregulation due to p65 overexpression is inconsistent with the structure of EGFR protein-protein interactions, in which p65 is far downstream of STAT.
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Our results showed that this location was far downstream from the flame anchoring zone, near the end of the recirculation zone.
You must exert prudence, however, before dashing off to the mailbox every other day, advises Yamamoto: "You should wait until you're far downstream in the negotiations" before penning notes and letters to current or future employers confirming negotiation details. "You have to know when to do these things".
The alpha lobes are far downstream from the calyx and the presumptive site of Drep2 action, and probably not important for STM.
First, the expression readout may be far downstream of the actual binding target and may lead to the pathway of action but not the direct protein target of the molecule.
In our opinion, the best phenotypes to examine in genetic analyses of renal aging should not be far downstream of the disease cascade; for example, examining nephrosclerotic changes in the early stage of their evolution and in the absence of confounding kidney disease could make detection of subtle changes possible even before they actually effect kidney function.
Peat landslides cause significant environmental impacts at-a-site, and their runout is far traveled causing considerable downstream devastation to infrastructure and stream ecology.
Mr Bhidé argues that this downstream innovation, which is far more complex and customised than the original upstream invention, is the most valuable kind and what America is best at.
Downstream of the BRWMU, the watershed is far less restricted.
Downstream, though, the effects of losing nutrient-rich sediments is far more problematic.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com