Sentence examples for is extremely deleterious from inspiring English sources

In addition, NO can combine with O2- to form a more toxic ONOO, which is extremely deleterious to the cells [ 37].

Because unchecked activity of the AHR pathway also is extremely deleterious, activation of this pathway is also accompanied by increased AHRR expression, which is associated with both demethylation and transcription factor binding to the cg05575921 locus.

His experience in the health service in Bradford had convinced him that cheap cigarettes were extremely deleterious to the health of the Asian community.

An allele similar to the patients' germ line mutation was previously studied in mice and found to be extremely deleterious in T cells.

Both hypovolemia and hypoxemia are extremely deleterious for the recently injured brain.

A deleterious effect of nLTR-RT related to the length of the elements has previously been described in Drosophila and in humans (Boissinot et al. 2001, 2006; Petrov et al. 2003, 2011) and results from the greater ability of long elements to mediate ectopic recombination events, which are extremely deleterious (Langley et al. 1988; Song and Boissinot 2007).

For genetic counselling purposes, it is extremely important to differentiate between deleterious and polymorphic splice-site alterations.

The long-term effect is difficult to fully characterize, because the SSR is only a pre-deleterious allele and its impact on fitness will be only moderate unless the deleterious frame-shifted allele is extremely likely to appear and is associated with a strong impact on fitness.

It is extremely difficult to draw a sharp line between the deleterious effects of normal aging and the deleterious effects of the diseases of aging.

This is extremely important clinically as it ensures that, where appropriate, the most deleterious potential consequence of a variant can be investigated (e.g., Fig.  1).

The mutator phenotype is suppressed by the resulting mutational load only under extreme parameters: where deleterious mutations are common, the cost of deleterious mutations is prohibitively high, and the benefit for driver mutations is extremely low.