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A complex interaction between MMR and BER repair systems, that is, exposure dependent, also exists to determine cellular toxicity.
Results suggest the presence of MSH2 dependent and independent pathways to determine cellular toxicity induced by oxidising agents and a complex interaction between MMR and BER repair systems in determining cellular toxicity that is exposure dependent.
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The frequency for mutation of the K-ras gene was exposure dependent.
Such a failure of a chemical to reach the target cells could be exposure dependent.
Thus, increased gene expression was exposure dependent with a no-effect-level (NOEL).
In these studies, tissue damage was exposure dependent, increasing with amount of force or cyclical loading, frequency or chronicity of loading, and recovery time between bouts of loading.
Since FA-dependent DPX is well established to be exposure dependent in vitro and in other in vivo studies, the absence of exposure-dependent effects at mean concentrations from 0.4 to 2.24 ppm is inexplicable.
A TP model could be used to evaluate theoretically various stages in a TP that are exposure dependent and important to the apical response and thus play an important role in helping to identify critical in vitro end points that can serve as biomarkers for apical end points.
The association was exposure-dependent and stronger among women.
The inverse association was exposure-dependent, it was almost identical after exclusion of the first year of follow-up and it was present among both women and men with no evidence for significant interaction by sex.
Cancer effects are exposure-dependent as shown from animal studies (Table 1) and thus potential risks may be characterized more easily from the cohorts with occupational exposures that are much higher than indoor air concentrations.> -wrap-foot> The US National Cancer Institute (NCI) cohort comprised 25,619 workers employed in ten US formaldehyde producing or using facilities.
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CEO of Professional Science Editing for Scientists @ prosciediting.com