Because of the established role of capsule in resistance by E. coli to serum killing, chemical capsule inhibition would be expected to sensitize encapsulated strains to serum exposure, thus attenuating infection and providing a useful therapeutic intervention.
Furthermore, it would be expected to sensitize tumors to induction of apoptosis by cytotoxic agents and, perhaps, in combination with EGFR inhibitors in triple-negative breast cancer and with drugs such as rapamycin that cause the feedback activation of PI3K/Akt signaling [38].
(81, 82) From these findings, inhibitors of oncogenic tyrosine kinases are expected to sensitize cancer cells to DNA-damaging agents.
AWWs and ASHAs are expected to sensitize and motivate families to use immunization services; auxiliary nurse-midwives (ANMs) are responsible for providing the vaccines.
Release of BDNF into the lumbar cord would be expected to sensitize the nociceptive pathway in the dorsal horn (Kerr et al., 1999; Garraway et al., 2003).
Thus, children enter primary school one by one, which can be expected to sensitize teachers for their relatively young age and to allow them to pay attention specifically to these youngest children.
He is expected to see an interactive exhibition designed by the Japan Committee to sensitize the public – and especially students – to critical issues affecting the world's children.
Such enzyme prodrug therapy, based on engineered and immunoisolated E. coli, may ultimately yield an improved therapeutic index relative to monotherapy, as AMF mediated hyperthermia might be expected to pre-sensitize tumors to chemotherapy under appropriate conditions.
