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Our data on metformin outcomes are consistent with the interpretation that metformin acts, at least in part, as a dietary restriction mimetic in C. elegans and suggest that this activity is executed via a mechanism that is conserved from nematodes to humans.
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Importantly, the new version can be executed via a command line interface (i.e., it does not require the use of a Graphical User Interface).
The experiment was executed via a team of researchers who physically and verbally abused an inflatable doll in front of preschool-age children, which led the children to later mimic the behaviour of the adults by attacking the doll in the same fashion.
Randomization will be executed via a secure web-based data management system.
The different steps in the procedure, running from: 1) exclusion or inclusion of an ILI-patient on the basis of symptoms and frequency of reporting, 2) determination of the onset of symptoms by interpolation from previous and current responses, and 3) calculation of daily incidence were executed via a computer program specifically written for GIS.
The UPR is executed via distinct signaling cascades whereby an initial attempt to restore folding homeostasis in the endoplasmic reticulum during stress is complemented by an apoptotic response if the defect cannot be resolved.
The LSP's delivery operation is executed via medium-sized diesel vans with an assumed maximum capacity of about 300 parcels.
Communication with computer-controlled characters is executed via text windows, in which players chose from a menu of possible responses to the conversation being shown.
A change in wellhead pressure is executed via throttling on the wellhead valve.
Canonical Notch signaling is executed via the ternary Notch ICD/MAML1/CSL complex acting on the promoter of a downstream gene, yet various forms of non-canonical signaling exist, some of which bypass the need for nuclear localization of Notch.
The motion control is executed via RS232 Bluetooth and Radio-Control receiver.
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