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Such a flexibility, which resides in the stacked HEAT repeats, is essential for interaction with RanGTP or with NPCs.
Typically, tubulin inhibitors that bind to the colchicine binding site bear the trimethoxyphenyl (TMP) moiety which is essential for interaction with tubulin.
Using domain dissection and cross-linking mass spectrometry, we identified a unique region of Pih1p that is essential for interaction with Rvb1p/Rvb2p.
While the structure of the PleD from P. aeruginosa and the XCC4471GGDEF protein from Xanthomonas campestris showed the presence of compact interaction between the two consecutive, highly conserved glycines in the first two sites, generation of a G to R mutation in Sebox5 has disrupted the compactness which is essential for interaction with the c-di-GMP.
These results show that optineurin is essential for interaction of CYLD with ubiquitinated RIP.
The DNA binding domain is essential for interaction with the viral origin of plasmid replication (OriP) [10].
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Future studies should comprehensively examine the metal bioavailability in aquatic sediments, because this factor is essential for interactions between the abiotic and biotic components of an aquatic ecosystem [2].
ATP processing by MutL is essential for interactions with MutH and UvrD [4], [13].
The G domain is highly conserved, typical of all GTPases [ 19], and the C domain is essential for interactions with eRF1 [ 11, 61, 62].
The skin constitutes a key interface in the development of vector-borne diseases, and vectors' saliva is essential for interactions between arthropod, parasite, and host.
These studies revealed two structural characteristics of DH and its agonists that are essential for interaction with the receptor: a trans-Pro configuration to form a type I β-turn and a hydrophobic moiety involved in ligand binding.
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CEO of Professional Science Editing for Scientists @ prosciediting.com