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The aminoacyl-tRNA synthetase (RS) is engineered to recognize unnatural amino acids by mutating the active site, based on a known structure [6], [7].
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When engineering NR, the DNA binding domain (DBD) of these receptors can be engineered to recognize an artificial promoter containing multimeric-binding sites and a minimal promoter [ 1, 2, 21].
T cells themselves may be engineered to recognize, bind to, and kill cancer cells.
By using antibodies, the nanoantenna can be engineered to recognize only specific bacterial species.
Nanobiomaterials can be engineered to recognize cancer-specific receptors at the cellular level for diagnostic and therapeutic purposes.
This work constitutes a successful proof of concept demonstrating that nanobodies can be engineered to recognize RNA-related epitopes.
Church believes the day is near when drugs will be engineered to recognize tumors and individuals can affordably have their genomes sequenced, revolutionizing personal medical treatment.
In this study, the Escherichia coli regulatory protein AraC was engineered to recognize ectoine as its non-natural effector and to activate transcription upon ectoine binding.
Moreover, DNA can be used as a promising material for nanobiotechnology, and the nanostructures of DNA can be engineered to recognize a variety of molecules.
TALE DNA binding domains were engineered to recognize sequences adjacent to Wnt responsive enhancer elements (WREs) that control expression of axis inhibition protein 2 (andN2) and c-MYC (MYC).
Recently, Acidaminococcus sp. BV3L6 (AsCpf1) was engineered to recognize altered DNA sequences as the protospacer adjacent motif (PAM), thereby expanding the target range of Cpf1-mediated genome editing.
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