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This protein is engaged upon Y. pseudotuberculosis-mediated β1-integrin activation and localizes to phagocytic cups.
To distinguish it from the "canonical" NLRP3 activation pathway that is engaged upon ATP or Nigericin stimulation, this inflammasome axis requiring caspase-11 was termed "non-canonical".
Closed-state inactivation is engaged upon small depolarizations (these allow the movement of the S4 voltage sensors in domains III and IV only, which is enough for the inactivation particle to move into the pore before the channel opens).
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And tThe more complex and extensive a problem is, the more it matters that as many people and organisations as possible are engaged upon solutions.
It isn't night feeds that she and I are engaged upon, although sometimes the nocturnal wakings, the dark loneliness, the wild swings from hope to despair bring those to mind.
Over the four years during which they have been engaged upon this project, orchestral players and soloist have clearly honed not only their individual performances but also their acutely sensitive responses towards each other's momentary needs.
In August 1939 the home secretary, Sir Samuel Hoare, justified legislation rushed through in a week by referring to the "S Plan", a "remarkable document" uncovered by police that, he said, indicated the IRA was intent on attacking the water, transport and electricity systems, and was "engaged upon a plan to blow up the Houses of Parliament".
Dopaminergic and stress response pathways jointly are engaged upon the commencement of alcohol consumption.
Signaling modules that activate NF-κB downstream of TLR4 are engaged upon BCR activation.
Altered signalling pathways that block cell death might be engaged upon loss of integrin contacts with the extracellular matrix and restored upon reestablishment of these contacts.
Our results demonstrate that mediators of the TLR4 signaling pathway to NF-κB are engaged upon BCR activation to contribute to B cell proliferation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com