Cell cycle progression can reach a state where Cdh1 is enabled to change from 0 to 1 and Cdc20 is ready to change from 1 to 0. If Cdh1 changes first, the cell cycle proceeds normally and reaches G1, but, if Cdc20 changes first, Cdh1 stops trying to change, causing the cell cycle to halt before reaching G1.
However, if Mcm1 changes first, Cdc20 is enabled to change from 0 to 1.
When multiple variables are enabled to change, one of them is chosen arbitrarily.
After Clb5 transitions to 1, both Clb2 and Mcm1 are enabled to change from 0 to 1.
Unlike the synchronous update rule, the asynchronous update rule allows a maximum of one variable to be updated at each time instant, and if multiple variables are enabled to change, one of them is chosen arbitrarily.
Note that the asynchronous update rule allows a maximum of one variable to be updated at each time instant, and if multiple variables are enabled to change, one of them is chosen in an arbitrary fashion.
In the application of the asynchronous update rule, those previously published Boolean models can generate the hazard since Cdc20 can be activated before the transcription of Clb2 if Mcm1 is activated first under the condition that both Clb2 and Mcm1 are enabled to change.
Consequently, the curve corresponding to the zero level set of this potential function is enabled to handle topological changes, such as splitting and merging.
"I think measuring people's commitment to the implementation and to the Model of Care is very telling so that's really very important…how they've been engaged and enabled to change whatever it is that they have needed to change.
They described Muncie, which they only ever referred to as Middletown, as "a community as small as thirty-odd thousand... [in which] the field staff was enabled to concentrate on cultural change... the interplay of a relatively constant... American stock and its changing environment".
Agents of change Underscoring Ms. Adams' observation that girls' education can create a cascade of positive outcomes in the lives of women around the world, Ms. Pruri said: "Girls and women can be enabled to be agents of change, and we hope to be midwife to some of that".
