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At which point, the question becomes unavoidable: is efficacy now to be the benchmark for persecutors?
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The other question is efficacy.
The importance of the clinical trial as the method of choice to determine efficacy is now well established, and the analytic techniques to conduct trials robustly are now so sophisticated that expertise is clustered in clinical trials units [ 38 ].
Yet the preliminary results of NCAR's experiments, which are being done in Mexico and are due to run for another year, suggest that solid evidence of the technique's efficacy is now within the researchers' grasp.In this section No PERVersion Cloudbusting An ice idea Inside out ReprintsSeeds of faithThe term "rain-makers" is actually a bit misleading: rain-boosters would be better.
The importance of the immune response against tumor antigens in virotherapy efficacy is now well recognized, however, its relative contribution versus the intrinsic oncolytic capacity of viruses has been difficult to evaluate.
Since the 1950s, chemical insecticides have been massively used for controlling mosquito populations but their efficacy is now threatened by resistance mechanisms developed by insects.
Chemoradiotherapy with FOLFOX4, a well-tolerated and convenient combination with promising efficacy, is now being tested in a phase III trial.
Direct comparison of efficacy is now possible due to availability of results from several head-to-head trials of these two medications.
Although policy initiatives for prevention and control of CVD and other chronic diseases in India have been proposed earlier [ 4], some evidence for their efficacy is now emerging within the country.
Some of them have already progressed to the level of phase II and pivotal trials, indicating that initial safety questions with EpCAM-directed therapeutic approaches have been successfully addressed in preceding phase 1 studies and that the assessment of clinical efficacy is now of primary interest.
A formal prospective paediatric efficacy study is now needed.
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