Because V appears to localize both intracellularly and systemically in the host, compounds that effectively block the interaction of V and its intracellular protein target(s) could also be effective in impeding or preventing the overall disease progression.
Preoperative chemotherapy is effective in improving the prognosis of patients, but its efficacy is impeded by cancer associated fibroblasts (CAFs) that enhance the survival, growth, and metastasis of cancer cells.
5-ASA treatment was effective in reducing PAK1 expression in small polyps and thereby impeding with tumor progression into large polyps.
Although an FRO might be effective in this respect, ankle push-off power is obstructed by an impeded plantar flexion in terminal stance and preswing.
These results indicate that protein synthesis inhibitors may be effective in many types of chemo-resistant cancers as they can induce apoptosis, inhibit proliferation and impede clonogenic potential even after the inhibitor is removed.
Community demand-side interventions to improve accessibility and uptake of facility-based care appear to be effective in many settings, particularly where quality facility-based care is available but cost of services or transport impedes care-seeking.
Moreover, because the control of E2F activity appears to be the end result of G1 regulatory cascades, the ability to inhibit E2F may be particularly effective in impeding a wide variety of proliferative events.
Surface wear scars also indicated that the proposed design was more effective in impeding the ingression of abrasive particles than the o-ring seal.
This study has shown that denying vehicle entrance to an area can be very effective in impeding vehicle-borne explosive attacks.
HrpNEa-induced resistance was also effective in impeding infestations of aphids, an important type of phloem-feeding herbivores [ 9, 10].
