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Whether this is due to wrong instrument choice or the difficulty of overcoming barriers for this group cannot be settled from the empirical evidence.
How much of the variation is due to wrong cell ID? Highly accurate cell identification seems extremely critical.
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If we are not willing to agree with Silberstein and Viswanathan that migraine and TTH are a continuum, it might be due to wrong diagnosis.
We must emphasise, nevertheless, that most inaccuracies in OPSIN output are due to wrong compound nomenclature in the CIFs and not to OPSIN malfunction.
When all targets with significant biases are removed from the benchmarking, a subset of 47 targets remains, for which Glide succeeded for only 5 targets, Gold for 4 and FlexX and Surflex for 2. The performance dramatic drop of all four programs when the biases are removed shows that we should beware of virtual screening benchmarks, because good performances may be due to wrong reasons.
Moreover, the fact that X. fastidiosa prophage-like elements are related to several groups of phages, may be potentially misleading and be due to wrong models of viral taxonomical classification (currently based on features encoded by a minority of their genes), as long debated in the literature.
Three out of four permanent harms were due to wrong administration of drugs.
Most of the untraceable controls were due to wrong or inexistent addresses in the Population Registry.
The long delay in providing conclusive evidence was due to wrong study design and to extreme exposure misclassification.
This may be due to wrong haemoglobin results, failure to assess patients appropriately, or avoidable use of emergency O RhD negative units because of poor communication or planning.
This may be due to wrong perceptions of causation which lead them to seek care from traditional healers instead of modern health facilities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com