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Cellular poly(ADP-ribose) (PAR) formation is dramatically stimulated upon DNA damage, and, as a result, NAD+ levels plummet when DNA is damaged [ 6, 7].
In addition, it has been observed that outward movement of lysosomes is dramatically stimulated when cytoplasmic pH is lowered (Heuser, 1989).
Whereas the Exo1 nuclease pathway has been shown to function independently of the Sgs1/BLM helicase, it has also been demonstrated that human ExoI resection activity is dramatically stimulated by a physical association with BLM [ 36, 37].
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Serum paraoxonase-1 (PON1) is a lipophilic lactonase whose stability and enzymatic activity are dramatically stimulated when associated with high-density lipoprotein (HDL) particles.
Furthermore, this interaction was dramatically stimulated by PTH treatment.
Consistently with our expectations, under 5% serum plus miR-C lentivirus, neuronal differentiation was dramatically stimulated, as confirmed by massive activation of neuron-specific β-tubulin (Fig. 5C, top), Emx2-mRNA level decreased, by about 30% (Fig. 5C, bottom-right), and Emx2OS-ncRNA was only slightly downregulated (Fig. 5C, bottom-left).
In the presence of Sec17, however, Sly1 binding was dramatically stimulated.
This is clearly seen for the C type lectins which are dramatically stimulated by IL-1β (18 fold) whilst they are increased 6.5 fold by IFN-γ.
When cells suffer cellular stresses, the level of autophagy could be dramatically stimulated as a cytoprotective response to cope with stresses, resulting in adaptation and survival.
Furthermore, in vitro biochemical analyses demonstrated that the enzymatic activities of both HerA and NurA were dramatically stimulated upon complex formation [ 84].
However, after breaker, expression of calmodulins was dramatically stimulated and reached the second peak at pink stage when they were even higher than the first peak during fruit enlargement.
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