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The mediator loop region is formed between A4518 and G4527 and is disordered in the structure.
The nicotinamide ring is disordered in crystals of this binary complex.
In particular, as shown in Supplementary Fig. 19c, we see that Q767 engages in interactions with the interface residues (such as E981) located below the AP-2 helix that refolds in this dimer (it is disordered in the monomer).
Previous structural studies showed that the N-terminal extension is disordered in the absence of DNA.
The prediction shows that almost half of the Atg31 sequence is disordered in solution (Fig. 5A).
According to our STM data, the surface is disordered in the direction perpendicular to the rows of the blocks.
For example, a pain is felt as being in a certain part of one's body, as if that part is disordered in a certain way; that is why pains are described as "burning," "stabbing," "throbbing" and the like.
Epithelial immunity is disordered in many common diseases and disordered epithelial differentiation underlies many cancers.
It has been shown that the CLIP containing segment is disordered in the absence of a bound MHCII heterodimer [19].
The corresponding residue in PaMpl is His210, but this region (residues 210 215) is disordered in our structure, probably due to the absence of metal ions.
The pKID domain (Asp119 Pro146) is disordered in the free form and folds into two α-helices upon binding to the structured KIX domain [26].
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