Sentence examples for is directly required from inspiring English sources

These data suggest that Egr1 is directly required in the sAPPs-induced axon outgrowth and not in dendrite outgrowth responses.

In such clones, we would not be able to determine whether GSCs are still attached to the hub and thus, whether E-cadherin is directly required for stem cell polarity.

Therefore, it appears that the V3 loop, particularly its "N44 region", is directly required for interaction of SU with the entry receptor CXCR4 but not with the binding receptor CD134.

However, insulin signaling is directly required for GSC maintenance with age.

This caused reduced Ca2+ currents and a defective glutamate release suggesting that PrPC function is directly required for synaptic Ca2+ signaling and vesicular release.

Here we employ fission yeast to show that Aurora (Ark1) kinase activity is directly required to maintain spindle checkpoint arrest, even in the presence of many unattached kinetochores.

Taken together, we suggest that Cdk9 activity and hence the phosphorylation of RNAPII or NELF is likely to be directly required for NSpt5's dominant negative effect in vivo.

Furthermore, this result supports our conclusion that RpoN would be directly required for hcp gene expression since in the ΔrpoN mutant the expression of Hcp was totally abolished despite the fact that in this mutant the level of HapR was increased.

Alternatively, cohesin's ATPase activity could be directly required for the acetylation reaction.

Parenthetically, this suggests that centromeres contain more CENP-A molecules than are directly required for the formation of a functional kinetochore.

Therefore, neither energy transduction nor conformational changes between the ATPase and the DNA binding domains of these enzymes are directly required for their nucleosome repositioning activity.