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This is partly due to the limits of the synthetic protocols: variation of the backbone to allow incorporation of heterogeneous building blocks is difficult in dendrimers, so that the character of the interior and surface of the dendrimers is difficult to vary in a differential manner.
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Nonetheless, they cautioned that the impact of the collaboration is difficult to quantify, they varied in how they gauged readiness, and they agreed that substantial work remains.
Their precise amount is difficult to reckon, because deals vary and details are seldom disclosed publicly.
VAP is difficult to diagnose and definitions vary.
The precise magnitude of the problem is difficult to ascertain because definitions vary and trafficking is a clandestine business.
However, accurate quantification of cause-specific mortality fractions for pneumonia and diarrheal diseases is difficult to achieve; current estimates vary substantially across modeling groups.
Despite being the most common endocrinopathy disorder, believed to affect 6-10% of reproductive-age women, PCOS is the least understood and this may be attributable to the fact that PCOS is difficult to diagnose and symptoms vary in both presence and severity [ 4, 5].
Prajñā, which could be translated as "wisdom" or as "discernment," is difficult to define and varies subtly in meaning among different Buddhist lineages.
The risk of progression is difficult to assess and varies in the literature from less than 1 to 20%.
The exact incidence is difficult to determine and varies dependent on the population studied and the diagnostic methods in use [ 3].
Creativity is difficult to assess because it varies according to the characteristics of the journal, such as its publication region, readers, authors, and editors.
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