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Until more information is available, it is difficult to inform either policy makers (in terms of potential changes to national screening programmes) or individual women on the balance between costs and effectiveness of screening below 50 years.
It is difficult to inform eligible persons in a way that ensures valid informed consent [ 68, 69] or assent as the evidence of long-term effectiveness and safety of bariatric procedures is not clear.
Without sound data, it is difficult to inform health policy and programmes.
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Di Matteo admitted it had been "difficult" to inform his captain he would not be starting, and conceded some semblance of defensive solidity must be restored in Turin.
While aircraft-level impacts are an obvious metric of success, it is difficult to make informed robust technology investment decisions with respect to noise without understanding the fleet-level impacts.
Without knowledge of the complete model it is difficult to make informed judgements about either the quality of the evidence or its applicability [ 2, 8, 15, 16].
However, it is difficult to find data to inform such estimates.
It is difficult to decide when to inform parents of the range of possible manifestations associated with a pathogenic CNV.
While the latter is difficult to address, implementing educative measures to inform relevant personnel about the negative side-effects and better species-site matching could show fast and cost-efficient improvements in the reduction of the practice of overpruning and therewith the danger of reduced aesthetic value of Arecaceae, undermining the purpose of their original planting.
However, while attention-getting vocalisations may not be designed to inform, it is difficult to argue that they do not do so [ 60], which in our opinion make such findings relevant to understand the origins of "meaningful" communication, including language [ 26].
In this frenetic environment, informed consent is difficult to secure, and research sampling becomes a secondary concern.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com