Our finding that changing prescribing of antithrombotics in AF is difficult to change is consistent with large surveys conducted over the last 10 15 years, demonstrating little improvement in the uptake of anticoagulants in patients with AF at high risk of stroke.
It is difficult to change ethics law.
It sounds simple, but it is difficult to change business models.
"Culture, almost by definition, is difficult to change because it's so embedded".
Once a person has become a Muslim, it is difficult to change.
"During the season it is difficult to change; you have to keep things simple for the players.
"I think the culture in Albany is difficult to change, but this is an opportunity," said Rachel Leon, the group's executive director.
But it is difficult to change the habits of a lifetime and each country's spies have spent theirs guarding and conspiring against the other's.
Station controller Bob Shennan, who has highlighted the number of women he has introduced elsewhere into the schedule, has previously said it is difficult to change the daytime lineup because the presenters are so popular.
"Once you have got a course accepted by the university and gone through the accreditation process for the Association of MBAs (Amba) it is difficult to change it and it gets set in stone.
It is difficult to change a Christian's mind about morality using a secular argument, so Democrats must seize the lever of tolerance and diversity and use it to force apart church and state.
