Because Web speeds vary minute to minute owing to traffic, such a claim is difficult to benchmark.
Manual interrogation of genome browsers for a range of functional annotations simultaneously does not, however, scale well for large studies, lacks reproducibility, is unsystematic and is difficult to benchmark.
Although it is difficult to rigorously benchmark the accuracy of genome annotation, our manual analysis of selected genomes indicated high quality annotation of UniFam.
As such types of studies are scarce, it is difficult to have a benchmark to compare the marginal yield and the welfare effect of contract participation.
Because prior knowledge on the expression conservation for human-mouse orthologs is limited (expression conservation may not be associated with sequence conservation [5], [12], [13], [14], [15]), it is difficult to establish a benchmark for accurately evaluating the computational methods used for assessing expression conservation in terms of sensitivity and specificity.
When studying complex phenotypes, it is difficult to establish a benchmark.
Therefore, it is difficult to find good benchmarks for quality.
However it is difficult to find a suitable benchmark to globally validate our results since the complexes within our triplets may have distinct biological functions.
However, it is difficult to establish a universal benchmark Ki (or Kd) below which a specific binding is defined because of different methods and assay conditions used across the studies.
The uncertainty associated with discharge measurement in storm sewer systems is of fundamental importance for hydrologic/hydraulic model calibration and pollutant load estimation, although it is difficult to determine as field benchmarks are generally impractical.
It is difficult to forecast without any benchmarks.
