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When the stacking fault energy is too low, the grain size lies below 15 nm after SPD processing and the stacking faults are saturated so that it is difficult to accumulate dislocations and deformation twins during the subsequent tensile testing.
In the regions of extensively hydrated plate boundaries that produce abundant clay minerals such as chlorite, a large elastic strain is difficult to accumulate and does not generate large thrust earthquakes, whereas the regions escaped from the hydration reactions could result in a strong mechanical coupling that acts as a seismic asperity.
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But killing large numbers of people with chemical weapons would require a big stockpile of deadly substances which would be difficult to accumulate without attracting suspicion.
Moreover, acetyl-CoA is native to E. coli in large amounts, whereas branched-chain substrates for FabHB are difficult to accumulate in E. coli [ 46, 55].
Given the relatively low mutation rate of SNPs, even 250 SNPs can be difficult to accumulate in systems where bacteria introduction is relatively recent (see examples given in the methods section).
The case numbers were difficult to accumulate in a short time because most blunt chest traumas could be treated with non-surgical methods and only about 10% of blunt chest injuries will evolve to retained pleural collections where surgical interventions should be arranged.
For these reasons, it is difficult to unequivocally determine accumulated ironoxide nanoparticles in tissues, which appear dark on MR images or in neighborhood of other signal distorting structures.
And for all of Mr. Meledandri's talk about lean and mean, it is difficult to stop fat from accumulating at a company over time.
For both incubators the turbidimetric readout method (Figure 2A) is difficult to interpret, but turbidity due to accumulating LAMP product is observed (relative to the no-template control, or NTC).
Although the magnitude of return migration is difficult to measure, the fact that migrants accumulate knowledge and financial capital in rich countries before spending the rest of their career in their origin country is also a potential important and positive feedback (Dos Santos and Postel-Vinay, 2003 1996).
It is difficult to prove stochastic sequence errors actually accumulate in a clock-like manner, and error rates may potentially fluctuate in response to environmental changes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com