Sentence examples for is difficult to accrue from inspiring English sources

It is difficult to accrue to randomized trials involving aggressive surgery, because patients often cannot comprehend that a "flip of the coin" could determine whether or not they undergo prolonged surgery with the associated risk of complications and death or perhaps go untreated for an imminently terminal condition.

Additionally, it has been difficult to accrue sufficient patient numbers for identification and validation of genetic risk modifiers with relatively modest effect sizes.

Thus, most studies with modest to large subject populations with advanced, metastatic BCC will be difficult to accrue.

These are difficult to fund, and it is hard to accrue adequate numbers of appropriate, eligible patients.

Considerable evidence indicates that once fat is accrued in humans, especially in adolescents, it is difficult to reverse that and most individuals remain overweight or obese for life [58], [59].

Given that S0102 excluded HER-2 overexpressing disease and accrued patients with relatively low prior anthracycline exposure and no prior taxane, it is difficult to find trials with similar populations for comparison.

Hence, despite very large sample numbers, it may be still difficult to accrue large enough sample populations for statistical comparison of Ep-CAM-negative with positive tumours.

It's hard to accrue enough time.

A major difficulty is that the costs of conserving such non-market goods and services are difficult to quantify in monetary terms and usually fall on the forest owner or manager, while the benefits largely accrue to society at large.

As prospective randomised studies have proved difficult to accrue to, current recommendations are based on the reports of large series of prospectively collected data.

That POI is a rarer condition than polycystic ovary syndrome or endometriosis makes it difficult to accrue the requisite sample size possible in studying those disorders (Uno et al., 2010; Chen et al., 2011a; Shi et al., 2012).