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The distribution of adaptive alleles in the ecological niche is determined by the emergence of novel mutations, their fitness consequences and gene flow that connects populations across species niches.
In some cases the entire action of a novel is determined by the locale in which it is set.
Consequently the safety of a new enzyme product from these novel genetically modified strains is determined by the background of the production organism.
"That is determined by the marketplace".
The quota is determined by the International Whaling Commission.
Committee membership is determined by the National Assembly.
Beer colour is determined by the malt.
(The moves are determined by the machine).
"It must be determined by the Senate.
Cap sizes are determined by the deal.
Protein was determined by the Bradford assay.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com