The substitution rate, however, is dependent on the shape of To explore this dependence, we constructed a simpler model where a fraction of all mutations is destabilizing (with change in free energy of folding ), a fraction is neutral, and a fraction is stabilizing (with change in free energy of folding ).
Even standard forms, like the blues tunes Gershwin wrote in "Porgy and Bess," were destabilized with overlays of other harmonies, other rhythms.
Songs with the three-chord structures of basic garage-rock, like "Bad Medicine" and "Mother" from the band's 1999 album "Fingerpainting" (Drag City), were destabilized with contrary drumbeats and stray guitar lines.
These differing steady-state ΣCO2 concentrations indicate that carbonate minerals are destabilized with increasing temperature in the komatiite-CO2-H2O system.
Thirteen young adults were destabilized with platform perturbations, and reached to grasp a nearby handrail to recover balance without stepping.
The authors found that 6 h before the flare, the NLFFF was destabilized with flux cancellation, the gas motion in characteristic of a sunspot moat flow or photospheric turbulent diffusion, and this resulted in the eruption.
In the case of myeloma, these regular cycles are destabilized with an increase in osteoclasts typical of this disease, and with corresponding destruction of bone mass and progressive tumor growth.
In contrast, in the interior of the α-helix, both post-translational modifications were destabilizing with respect to the α-helix, with the greatest destabilization seen for threonine OGlcNAcylation at residue 5 and threonine phosphorylation at residue 10, with peptides containing either post-translational modification existing as random coils.
At the C-terminus, both OGlcNAcylation and phosphorylation were destabilizing with respect to the α-helix, though the induced structural changes were less than in the interior of the α-helix.
The base pairing properties of 8-halo-7-deaza-dG were studied by measuring the thermal denaturation temperature of the duplexes, showing that their base pair with dC is destabilized compared with natural dG.
