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A 'lead' compound is designated when a series of criteria (including potency, selectivity, synthetic access, 'drug-like' properties [see later] and potential for further optimisation) are met.
Similar(59)
The grounds of the demurrer to them will be designated when the counts are separately considered.
The arrival of the ruin pubs could not have come sooner for beleaguered Budapest VII (as the city's districts are designated; when in Budapest, do as the Romans do).
was designated when US 13 was moved to the Salisbury Bypass upon its completion in 1982.
The state highway was designated when US 40 bypassed Eckhart Mines around 1950.
The route was designated when US 8 was shifted to a bypass of downtown in the 1990s.
MD 657 was designated when that county highway was brought into the state highway system in 1939.
As all tissue specimens analyzed were from individuals harboring frameshift mutations, the mutant and wild-type alleles could readily be distinguished; loss of the wild-type allele was designated when the radiographic intensity of this allele was ≤25% of the mutant allele.
Hormone receptor positivity was designated when either ER or PR was positive.
Hormone receptor (HR) positivity was designated when either ER or PR was positive.
Randomisation was designated when internal temperature was ≥ 38°C lasting longer than 30 min. Drugs were used till clinically necessary.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com