Additionally, some ovarian cell types are derived externally, such as the primordial germ cells from the yolk sac and the immune cells, which are derived from the hematopoietic stem cells that originated from the dorsal aorta in the aorta-gonad-mesonephros region (reviewed in Ref. 9).
The relationship between a surrogate and the true endpoint should be also validated internally, within the population from which it is derived, and externally by other centres.
Regarding step 2, one may question whether Mn is derived locally from the host rock or externally via atmospheric transportation [8].
An analytical solution is derived in this work for the strength of a general externally bonded interface.
For both subsets, descriptive and predictive QSAR models are derived, discussed and externally validated, revealing general trends in relationships between molecular structure and binding affinity constants in structurally diverse datasets.
Having examined the classification accuracies by cross-validation on the same datasets from which the classifiers were derived, the accuracies were then re-assessed by externally validating on independent datasets with identical phenotypic class labels.
19 23 24 The algorithm was derived using multinomial response mapping, validated internally and externally using the 2000 US Medical Expenditure Panel Survey (MEPS), generating index values for eight countries: the UK, the USA, Spain, Germany, the Netherlands, Denmark, Japan and Zimbabwe.
The optimal model was validated internally and externally and several statistical stringent parameters were derived.
The GRACE risk score (2.0) was derived in 32 037 patients from the GRACE registry (14 countries, 94 hospitals) and validated externally in the French registry of Acute ST-elevation and non-ST-elevation MI (FAST-MI) 2005.
To make an objective comparison of phylogenetic and niche maps based on niche similarity, we applied a metric that, although arguably not ideal, is externally derived and relates to the environmental and functional definition of a niche.
Thus, PM requires a fine attentional balance between information that is externally derived (e.g., monitoring the traffic) versus internally maintained (e.g., the intention).
