Also, the power of a combination of approaches such as homology modeling and biased MD with conventional MD, when any single computational technique is insufficient, is demonstrated.
However, some of the latter studies (Demopoulos et al. 1997; Dziekan et al. 1998) utilized a reactive hyperemic stimulus involving only 5 min of forearm ischemia, a stimulus which has repeatedly been demonstrated as insufficient to induce a true maximal hyperemic responses (Naylor et al. 2005; Sinoway et al. 1986; Takeshita and Mark 1980).
However, GGH overexpression was demonstrated to be insufficient to produce resistance to the drug in a human fibrosarcoma HT-10800) and a human breast carcinoma (MCF-7) cell line [ 28].
For instance, carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 199, CA 125 and α-fetoprotein (AFP) were demonstrated to have insufficient sensitivity for testing for cancer and are currently used solely to detect a single type of the disease [ 1– 3].
As Y is a pure beta emitter, the only way to (quantitatively) assess the biodistribution of the SIR-Spheres® and TheraSphere® microspheres would be by means of Bremsstrahlung scans of which the quality has unfortunately been demonstrated to be insufficient for this purpose.
Patients who have a HADS score of 8-21 inclusive will receive the medium-intensity Intervention, irrespective of the presence or absence of risk factors Simple provision of information alone has been demonstrated to be insufficient to treat depressed patients [ 33], meaning that a more intensive Intervention is required for depressed patients [ 34].
In diabetes mellitus type 2, for instance, it has been demonstrated that there is insufficient evidence for many widely used quality indicators regarding their predictive power for clinically relevant outcomes [ 22].
We were able to demonstrate a significantly better survival of the INT subtype not only for AMPAC but also in the subgroups of DUOAC and PDAC, which has not been demonstrated before due to insufficient case numbers [ 3, 9].
The mean duration of sepsis was comparable between study periods, 3.6 days (Range: 1 to 10 days) versus 3.4 days (Range: 1 to 12 days); although non-inferiority of a restricted vancomycin policy could not be demonstrated potentially due to insufficient sample size.
Although non-inferiority of a restricted vancomycin policy could not be demonstrated (potentially due to insufficient sample size), the mean duration of sepsis among infants treated with empiric cloxacillin and gentamicin was comparable to that among infants treated with empiric vancomycin.
On the other hand, it is worth stressing that it has been demonstrated that anharmonicity alone is insufficient to ensure normal heat conduction [23], in one-dimensional lattice chains.
