Sentence examples for is deleterious at from inspiring English sources
It has been shown that Trf1 deletion is deleterious at early points of development (Karlseder et al, 2003; Martinez et al, 2009).
However, although the absence of HuR translocation is likely beneficial at the initial stage of hyperinflammation, this effect is deleterious at the stage of immunoparalysis because the mRNAs of many immunostimulatory cytokines, including TNF-α, IFN-γ, and GM-CSF, contain classic "AUUUA" motifs within their 3′-UTRs, and their expression is thus tightly controlled by HuR.
In the acute setting, in those who suffer more protracted post-operative courses linked to adverse RV function, targeted resynchronization pacing could be of significant benefit in the immediate recovery period, especially since it seems clear that RV apical pacing is deleterious at worst and at best neutral in effect.
Childs, B. G. et al. Senescent intimal foam cells are deleterious at all stages of atherosclerosis.
In this model, a large number of the variations observed would be expected to be deleterious, at least to some extent.
Defects in this equilibrium can be deleterious at cellular and organism level, giving rise to various disease states.
As noted above, insertions in this gene conferred a growth advantage at 16°C and 23°C, but are deleterious at high temperature.
The biological effects of NF-κB-mediated metabolic inflammation are deleterious at cellular and tissue levels, including impairments of normal intracellular signaling and disruptions of metabolic physiology.
If mutants with δ = 0 are only considered, negative epistasis is rather frequent relative to additive neutral case: As much as 35% of the mutants are deleterious at d = 5 even if they carry only neutral substitutions.
Indeed, D153 added back in isolation is deleterious by at least 10-fold but beneficial by 230-fold when added in the otherwise WT background.
On the other hand, if melanism is deleterious and is being held at mutation-selection equilibrium, we might expect melanism caused by mutations in Agouti if they are recessive.
