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Although there is variation in susceptibility, each system is deficient in its protection capacity.
Thus, it is possible that the variant could produce a dominant-negative mutant that efficiently binds wild-type DLC1 monomers to form heterodimers that are deficient in its own function but amplifies the effect of CDK6, i.e., protective when CDK6 functions normally and risky when CDK6 is mutated.
Yet, each was deficient in its own way.
If BH4 is deficient in supply or function the eNOS reaction not only is capable of uncoupling with subsequent excess [O2'] and [ONOO'] but also is at a disadvantage in that there would be less BH4 to scavenge these local occurring reactive oxygen species being produced in excess amounts [ 27].
PINK1/parkin also appears to be important in mitochondrial function, which is deficient in Parkinson disease.
LOXIN is deficient in ox-LDL binding activity but interacts with LOX-1 receptors inhibiting its function through the formation of non-functional hetero-oligomers [18].
But it is deficient in two respects.
B-cell function can be normal but is deficient in approximately one third of patients.
India is deficient in both.
Our city is deficient in charm.
These cells are deficient in ept function and Psn activity, but give rise to easily detectable clones due to their inability to die.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com