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According to PolyPhen, the PITX3 p.R113P substitution is damaging with a high probability (score 2.6) and the PMut calculation predicts a highly reliable pathological effect.
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In contrast, DNA in D. radiodurans is damaged with essentially the same dose dependence as in all prokaryotic and eukaryotic cells examined [3], [5], [8].
In malignancies, when intercellular adhesion is damaged, with loss of membranous contact, ALCAM expression relocates in cell cytoplasm.
In addition, Polyphen2 (HumVar) predicts that this substitution is likely to be damaging with a score of 0.996.
Out of 8104 new variants, 542 (6.7%) were predicted to be damaging with 128 of them in asymmetric gene pairs.
About 4,260 homes were damaged, with around 500 severely damaged or destroyed.
Infrastructure at Woking was damaged, with disruption and delays expected until the end of the day.
The international image of the country was damaged, with numbers of female tourists dropping significantly.
The painting, by Ralph Heimans, which was put on public display last month, was damaged with paint at lunchtime on Thursday.
The painting, by Ralph Heimans, which was put on public display last month, was damaged with paint on Thursday lunchtime.
The World Health Organisation says 57% of Syria's public hospitals have been damaged, with 37% knocked out of service.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com