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Tadalafil (TDF) is a Biopharmaceutics Classification System (BCS) class II drug; the efficacy thereof is critically limited by inherent poor water solubility.
Human organ transplantation has improved duration and quality of life for many people, but its full potential is critically limited by short supply of available organs.
The use of resin transfer moulding (RTM) as an economic and efficient means of producing high-performance fibre-reinforced composites is critically limited by the permeability of the fabrics employed.
With the advancement in VLSI design technology which offers exponentially shrinking of device dimensions and exponentially growing circuit complexities, device scaling is critically limited by the power dissipation; demanding for better power optimizations methods like Reversible Logic.
Scientific literature on gestational diabetes in refugee camp settings is critically limited.
Because detection of alternative splicing events is critically limited by the number of junction fragments, we first combined the datasets to increase the sensitivity of detection.
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Conventional electroencephalography with disc electrodes has major drawbacks including poor spatial resolution, selectivity and low signal-to-noise ratio that are critically limiting its use.
For many applications, including metagenomics and the sequencing of ancient, forensic, and clinical samples, the quantity of input DNA can be critically limiting.
Transplantation experiments of typical reef sponges to mangrove roots revealed that reef species deteriorated quickly after transplantation to coastal mangrove roots (Farnsworth and Ellison 1996; Wulff 2004; Pawlik et al. 2007), where the root substrate is critically important in limiting survival of reef species in mangrove systems (Hunting et al. 2013), while mangrove species remain unaffected.
"UNICEF's Emergency Programme Fund is critically overstretched, greatly limiting our ability to provide urgent emergency funding within hours of a disaster," continued Ms. Veneman.
The development of efficient methods for generating clean and sustainable energy is critically important to limit harmful greenhouse-gas emissions from burning of fossil fuels and to meet the rapid increase in global energy demand.
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CEO of Professional Science Editing for Scientists @ prosciediting.com