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It seems that the protein synthesis machinery is critically impaired by staurosporine.
A variety of results in human and murine SLE are consistent with the possibility that selection is critically impaired in censoring autoreactive B cells after GC reactions.
These studies therefore define the TLR9 BTK calcineurin NFAT pathway as an innate intracellular recognition system that is critically impaired in transplant-related pulmonary aspergillosis.
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Surprisingly, expression of many genes related to host defense were critically impaired upon RU486 treatment, a mechanism that could explain unusual bacterial infections in individuals taking this compound as abortion pill and the beneficial effects of an acute therapy with GCs.
Dopamine receptors are involved in various responses such as motor control, neuroendocrine regulation, cognition, emotion and drug abuse that are critically impaired or associated with schizophrenia.
The hypophysis and hypothalamus are intracerebral organs, and if blood flow is inadequate then the function of these organs may be critically impaired.
Beyond a direct activity against microorganisms, HBO has been shown to re-establish defense mechanisms that are critically impaired by the typically hypoxic microenvironment in infectious sites [ 77].
In addition, the response of cancer cells to genotoxic therapies may be critically impaired by defects in the response mechanisms to DNA damage [ 3] or in cell cycle regulatory pathways [ 4].
As oxygenation was not critically impaired and there was a lower recruitment potential and a higher risk of volutrauma in inhomogeneous ARDS, we refrained from increasing mPaw when changing to HFOV.
So last month, in an announcement that could have come straight out of a Dan Brown novel, Icann announced that the internet would be protected by seven "guardians" on three different continents whose job would be to reboot the internet if the DNS system was ever critically impaired.
Relative to obesity without BED, impulsivity in BED does not appear to be as critically impaired across multiple domains as observed across disorders of addiction.
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CEO of Professional Science Editing for Scientists @ prosciediting.com