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How business models are changing in response to these is creating significant challenges — as well as opportunities.
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Operating and capital expenses of these new data centers are creating significant financial challenges for many information-technology-intensive companies.
At the same time that environmental problems are creating significant strains on the economy, there are pre-existing economic challenges in the region.
In addition to resource constraints, there were also health system failures that created significant challenges: 'When mistakes occur, it is a system failure not the level of competency'.
While these background conditions create significant challenges, they are challenges that need to be addressed and managed in the design and conduct of global biomedical research, which remains an important and fundamentally ethical pursuit, and essential to inform solutions to some of the world's most pressing health problems.
But if those plans are adopted, space reserved for a memorial below ground level could create significant challenges for officials in planning the underground elements of a rebuilt trade center site.
This selective decentralization of power generation, however, creates significant challenges, because current transmission and distribution grids were designed for centralized power generation and unidirectional flows.
This intricate landscape creates significant challenges for identifying and quantifying the diabetes risk that is attributable specifically to use of these medications.
This will create significant challenges for many micro businesses and sole traders, some experts warn.
Modern electronic commerce creates significant challenges for decision-makers.
The advance in NGS technologies has also created significant challenges in bioinformatics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com