Some of other top 12 descending genes are correlated with developmental pluripotency and are usually expressed in undifferentiated pluripotent stem cells (i.e., EPCAM and DPPA4) [ 25, 26].
Initially, these findings disconcerted researchers who thought the number of genes should be correlated with developmental and physiological complexity, and made them realize that other mechanisms should be involved in this evolutionary variety.
The observation that increased days of febrile illness is correlated with lower developmental scores suggests that persistent or repeated inflammatory insults may have a cumulative effect on developmental outcomes [ 31].
The maturation of visual acuity is correlated with the developmental decline of plasticity in the visual cortex [15].
Additionally, recent investigations with both knockdown and knockout mice have revealed that a complete lack of CDO activity is correlated with severe developmental problems, as well as drastically (∼90%) lower hepatic levels of taurine.
Knockdown of LSD1 induces differentiation in human ES cells, which is correlated with de-repression of developmental genes with elevated H3K4me2/3 levels [ 44].
Overall, our results show that in FLyA- and FLyB-treated cells, BRA binds to the genome in a manner that is correlated with the transcriptional and developmental identity of each cell population, endoderm and mesoderm, respectively.
Previous comparative studies of development between C. elegans and P. pacificus have also demonstrated that sequence divergence is correlated with divergence in a number of developmental processes [ 8– 10].
Marker expression past the appropriate developmental stage is correlated with genetic variation, including mutation in c-KIT [ 48] and its ligand (KITLG) [ 49], and DNA methylation [ 41].
This harsh environment probably also reduces the developmental rate, which is correlated with increased life span in some species.
