Sentence examples for is converted to active from inspiring English sources

In the host, inactive PLG is converted to active plasmin by host-expressed tissue-type PLG activator (tPA) and urokinase (uPA).

Previous investigators have suggested that big ET-1 is converted to active ET-1 in the lungs [ 38].

Using folate as a cofactor, the drug is converted to active nucleotides, such as fluorodeoxyuridine monophosphate, which inhibit the enzyme thymidylate synthase.

Fluorouracil is converted to active metabolites by phosphorylation through three different pathways, and TP and OPRT are the key enzymes in two of these pathways [ 13].

Approximately 70% of administered leflunomide is converted to active teriflunomide, predominately mediated by the CYP450 enzymes 1A2, 2C19, and 3A4, 9, 10 and carriage of the loss-of-function CYP2C19*2 allele has been associated with lower teriflunomide plasma concentrations.

When the antibody enzyme has cleared from the circulation, a prodrug is given and is converted to active drug in the tumour by the targeted enzyme (Bagshawe et al, 1988).

These zymogens are precursor enzymes that are converted to active enzymes by the cleavage of one or in some instances two peptide bonds.

Furthermore, stabilized TOP3 was cleaved by the hypoxic stress-induced endogenous caspases and thus the procaspase-3 was converted to active caspase-3 specifically under hypoxic conditions.

By the process of limited proteolysis, in which several cuts in the polypeptide chains of these cofactors are formed by the enzyme thrombin, factors V and VIII are converted to active cofactors.

This also allowed the FURA-2/AM to be converted to active FURA-2 by intracellular esterases.

In presence of aspirin, n-3 PUFA are converted to active substances named resolvins and protectins which play a pivotal role in the resolution of inflammation [29].