In addition to K63-linked ubiquitin conjugation, NEMO is conjugated with linear ubiquitin chains by the linear ubiquitin chain assembly complex, which is also involved in TNF α-induced NF- κB activation.
Further, it is essential to elucidate the structure activity relationship (SAR) of a drug when it is conjugated with a polymer using different conjugation sites, as this can vary the efficacy and mechanism of action when compared with its free form.
It is conjugated with a 40-kDa polyethylene glycol molecule to increase the t½ of the treatment to ~2 weeks.
We design the immunomodulatory CpG ODNs based platform that is conjugated with NIR-responsive gold nanorods and doxorubicin for cancer therapy.
It is released at the hepatocytic sinusoidal membrane and is transported to the smooth endoplasmic reticulum, where it is conjugated with one or two molecules of glucuronic acid and thereby becomes soluble in water and excretable in bile.
This intratumoral depot consists of recombinant elastin-like polypeptide (ELP) containing periodic cysteine residues and is conjugated with a photosensitizer, chlorin-e6 (Ce6) at the N-terminus of the ELP.
A colorimetric and ''turn-on" fluorescent chemosensor Rho-Fe3O4@SiO2 for Hg2+ in which N- rhodamine-6G lactam-ethylenediamine (Rho-eN- rhodamine-6G lactam-ethylenediaminee–shell Fe3O4@SiO2 N- rhodamine-6G lactam-ethylenediamined syN- rhodamine-6G lactam-ethylenediamine
We hypothesized that when poly ethylene glycol) (PEG) hydrogel, a non-adhesive tissue engineering scaffold, is conjugated with CMP, it may retain cell-secreted collagens and also form physical crosslinks that can be manipulated by cells.
To overcome this issue, we have designed a novel targeting anticancer 'hybrid-peptide' EGFR-lytic peptide, in which epidermal growth factor receptor (EGFR) binding peptide is conjugated with a newly designed lytic-type peptide containing cationic-rich amino acids that disintegrates the cell membrane to kill cancer cells.
Unconjugated bilirubin is carried by Albumin to the liver where it is conjugated with glucuronic acid and becomes water soluble.
HMF is first oxidized to carboxylic acid and is conjugated with glycine, leading to the formation of HMFG.
