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Most of the time, the embryo simply doesn't survive because its body layout is completely disordered.
In contrast, we did not observe any density at the same position in our map of the ATP + GBM state that was solved using the SUR1-Kir6.2 fusion construct, in which the C-terminus of SUR1 is covalently connected to the N-terminus of Kir6.2 by a linker (Fig. 2F) and the linker together with Kir6.2 N-terminus is completely disordered in our cryo-EM map.
Interestingly, G6 has one sequence that is completely disordered (Ir2-10518) that is also highly antigenic (>0.7).
The structural characterization by various spectroscopic techniques revealed that the 1500 amino acid long central region of BRCA1 is completely disordered [ 110].
No protected regions were detected, showing that, in the absence of the C-terminal domain and the liganded GA receptor, the RGL1 N-terminal domain is completely disordered along its entire length, including the conserved motifs.
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In fact, several Archaean domains are completely disordered and only ~2,000 domains are completely devoid disordered regions.
The solid morphology is assumed to be completely disordered throughout the process and is represented by a site-percolation model.
There is substantial lack of structural and biophysical information on N-ter domain; in particular, this domain appears to be completely disordered with the typical features of the natively unfolded protein [3].
The protein loops that interact with the nucleotide substrate are completely disordered, and a disorder-to-order transition is likely responsible for this substrate specificity.
Furthermore, some regions of the protein have high B factors or are completely disordered in the crystals, emphasizing the dynamic nature of the enzyme.
As expected based on the narrow line widths and low numbers of (only trivial) NOEs found, the last 7 C-terminal residues are completely disordered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com