Sentence examples for is completely defective from inspiring English sources

IL-1R signaling in TRAF6-deficient fibroblasts is completely defective.

Additionally, IL1-induced JNK and p38 activation is completely defective in cells lacking IRAK4.

At the non-permissive temperature (36°C), Cdc13-1 is completely defective and cdc13-1 mutares are unable to grow.

Although reagents that would enable direct visualization of the O-fucosylation state of Notch in cells expressing Ofut1 R 245 A do not exist, prior characterization of this mutant isoform indicates that it is completely defective in fucosylation [ 10].

This premise was derived from the finding that the espG/orf3/tir triple mutant is completely defective at causing a loss in TER much like the eae mutant, despite the presence of EspF and Map in these strains.

However, the amount of phosphorylated Rec8 was increased at the centromere in CUP-CLB3 cells compared to wild-type cells, albeit not to the same extent as in cells depleted for Sgo1 (sgo1-mn), in which meiosis I centromeric-cohesin protection is completely defective.

Importantly, the meiotic phenotype of dfp1-r35 suggests that disruption in prDSB formation is not its only defect, because rec12Δ mutants, which are completely defective for prDSB formation, nevertheless complete both meiotic divisions in with a normal timing and transcriptional program.

In Traf6 −/− cells, Q145N but not 2ED MAVS was completely defective in inducing IFNβ, but this defect was rescued by ectopic expression of WT but not C70A TRAF6.

"Maybe there's completely defective thinking [in the conventional view]," he says in the film.

Finally, we showed that double mutants between sid-1 and the yolk receptor were completely defective for inherited RNAi, even when SID-1 was expressed in the embryo.

Consistent with the result in Malt1 KO MEF cells, both CARMA3-deficient and BCL10-deficient cells were completely defective for NF-κB activation upon doxorubicin treatment.