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Understanding of membrane transport is comparatively advanced in trypanosomes [ 25, 26], and various cellular changes are associated with life cycle progression [ 6], most notably an order of magnitude increase in endocytic activity in the mammalian infective bloodstream form (BSF) versus the insect procyclic (PCF) stages [ 10].
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Those that are comparatively advanced in the development pipeline include the synthetic endoperoxidase OZ439, which has proven activity against the asexual stages of the parasite (6) and is currently in phase IIa clinical trials, and the spiroindolone NITD609, which has previously demonstrated potent dose-responsive activity against the sexual stages of Plasmodium falciparum (7).
These communes were selected on the basis of being involved in the program for an extended period, hence where program activities would be comparatively well advanced.
It occurs because, when the ignition is too advanced, the cylinder temperature is comparatively low.
Some IENs felt disillusioned after relocation to Canada, having realized that the system was not as comparatively advanced as they had expected: "I thought that the [Canadian] health care system would be really advanced.
The project is comparatively humble.
But screening is comparatively easy.
Divorce at this level is comparatively rare.
There is comparatively little immigration these days.
Ruscha's eminence is comparatively ghostly.
Independent figure sculpture is comparatively rare.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com